I've spend a couple of days working fulltime in Chrome, and it's improved my workflow.
Firefox disappears sometimes, I sit there waiting for my computer to come back. Doesn't seem to happen with Chrome even though I accumulate a ton of tabs, as with Firefox.
I've launched Firefox a few times to access Firebug. I haven't figured out how to get Chrome's builtin debugger to open in a separate window. Once I have that, I probably won't need to go to Firefox.